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KMID : 0869620060230040291
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Journal of Korean Society of Hospital Pharmacists
2006 Volume.23 No. 4 p.291 ~ p.303
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The Compatibility of Fluorouracil and Peripheral Hyperalimentation Admixtures
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Kim Sun-Mi
Lee Eun-Kyung
Min Myung-Sook
In Yong-Won
Sohn Kie-Ho
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Abstract
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This Study was performed to investigate the compatibility of Fluorouracil (5-FU) and Combiflex peri (Com-P) as peripheral hyperalimentation admixtures.
Four different conditions of intermixture were evaluated; additive form (5-FU was added to Com-P), group 1 (simultaneous administration of 5-FU diluted in 0.9% normal saline [NS] or 5% dextrose water [5DW] and Com-P via Y-site), group 2 (simultaneous administration of 5-FU added to Com-P and 20% lipid via Y-site), group 3 (simultaneous administration of 5-FU diluted in NS or 5DW and total nutrient admixtures [Com-TNA] composed of Com-P, 20% lipid, trace elements and multi vitamin via Y-site). Considering for prescription dose in clinical setting, 1,000 ㎎, 2,000 ㎎ and 3,000 ㎎ of 5-FU were tested. Appearance, pH, turbidity, insoluble particle counts, particle size and distribution were observed and 5-FU was quantitated. Additive form was checked at 0 (initial), 8, 24 and 48 hours thereafter. Group 1, 2 and 3, Y-site administration, were assessed immediately after mixing, 1 and 4 hours. Haze and precipitates occur immediately in additive form and group 2. In case of group 1, 5-FU diluted in NS was compatible with Com-P for all dose of 5-FU, but high dose of 5-FU (3,000 ㎎) increased the turbidity more than 10 NTU. Group 3 exhibited compatibility for all measurement and no additional foreign substance observation. Our finding suggested that 5-FU diluted in NS and low dose 5-FU (≤ 2,000 ㎎) diluted in 5DW could be co-infused with Com-P through Y-injection site if simultaneous administration was needed.
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KEYWORD
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Fluorouracil, Combiflex peri, hyperalimentation, Y-site, compatibility
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